In this work, we report that renal tubular specific Kim1 knockout relieves cisplatin and IR-injured AKI, unveiling a role for the YY1-KIM1-DR5 axis in the progression of AKI, our study also provides a proof-of-concept into AKI treatment through targeting the YY1-KIM1-DR5 axis (Fig. 8l). Here, YY1 is linked to acute kidney injury.