TNF and acute kidney injury: As in cisplatin-induced AKI mice, the mRNA levels of the AKI biomarker Ngal, inflammatory factors Tnfa, Mcp1, Il6, Cxcl2 and Cxcl10, apoptotic molecules Fas and Bax, and fibrotic factors Col1a1 and Fn1 were decreased in bIRI-injured Kim1Ksp KO mice (Fig. 7f–i).