However, transcription factors and signaling mediators that are substantially involved in the differentiation and activation of pro/anti-inflammatory profiles were downregulated (TBX21, GATA3, NFATC1, NFATC2, STAT4, STAT6, IRF4, JAK1, CREBBP), and that corresponds to the reduced expression of classical inflammatory responses seen in our TB patients55,56. The gene discussed is IRF4; the disease is tuberculosis.