TBX21 and tuberculosis: However, transcription factors and signaling mediators that are substantially involved in the differentiation and activation of pro/anti-inflammatory profiles were downregulated (TBX21, GATA3, NFATC1, NFATC2, STAT4, STAT6, IRF4, JAK1, CREBBP), and that corresponds to the reduced expression of classical inflammatory responses seen in our TB patients55,56.