VSIR and Miyoshi myopathy: In line with our findings of a potential role of PD-1H in MM bone disease is the finding that the gene expression level of PD-1H (MMRF CoMMpass study IA17 dataset) (https://research.themmrf.org) is significantly higher in MM patients with bone pain, reflecting active MM bone disease (mean: 139.2 TPM, N = 201) compared to those without bone pain (mean: 120.7 TPM, N = 111) (P = 0.0277 by two-tailed student’s t-test), supporting the proposition that PD-1H levels positively correlate with active bone disease in MM.