However, to determine whether A. muciniphila could block the inflammatory effect on GECs caused by F. nucleatum to inhibit periodontitis, we infected human GECs (C1052) with A. muciniphila and F. nucleatum alone and together (control, Fn, AKK, and Fn+Akk groups, multiplicity of infection (MOI) = 250) to further clarify the role of A. muciniphila. This evidence concerns the gene FN1 and infection.