To investigate how PRC2 and MLL–MEN1 complexes, which are involved in transcriptional repression and activation, respectively, demonstrate cooperative effects on lymphoma cell fitness, we performed CUT&Tag to profile genome-wide distribution of H3K27me3, MEN1, and MLL1 in both EZH2 wildtype (Farage) and mutant (KARPAS422) lymphoma lines. This evidence concerns the gene KMT2A and lymphoma.