Taken together, it appears that the redistribution of the MLL–MEN1 complex by H3K27me3 expansion drives a higher and MEN1-dependent expression of genes involved in key oncogenic pathways (e.g. mTORC1 signaling) that are required for the growth of EZH2 mutant DLBCL cells (Fig. 5h). Here, KMT2A is linked to diffuse large B-cell lymphoma.