EZH2 and neoplasm: The detrimental effect of CRISPR-Cas9-mediated knockout of MEN1 on the proliferation of EZH2 mutant lymphoma lines KARPAS422 and SuDHL4 was also evident in competitive proliferation assays (Fig. 3d), and in xenograft experiments where depletion of MEN1 decreased the incidence of tumor formation (Fig. 3e).