To determine how the immune system could be modulated by IL1R1+ iCAFs, we further subclustered tumor myeloid and T cells of the Lee and Qian scRNA-Seq datasets to identify macrophages (Supplementary Fig. 6a), CD4+ and CD8+ T cells as well as Tregs (Supplementary Fig. 6b). The gene discussed is CD8A; the disease is neoplasm.