We observed better survival (Supplementary Fig. 8f) and lower tumor volumes (Fig. 6d,e, Supplementary Fig. 8g) in ColVIcre+IL1R1fl/fl compared to their littermate ColVIcre-IL1R1fl/fl control mice, indicating that an IL-1-related crosstalk between CAFs and tumor cells plays a cancer-promoting role. This evidence concerns the gene IL1B and neoplasm.