The finding that treatment with MLN4924 could partially revert the repressive effects of TGFβ on NK cells effector activity against MM (Fig. 7 and Supplementary Fig. 13), in addition to the aforementioned direct boost of their degranulation activity, further extends the therapeutic potential of neddylation inhibition in this context. The gene discussed is TGFB1; the disease is Miyoshi myopathy.