TNF and Miyoshi myopathy: Inhibition of neddylation did not significantly alter the induction of cytokines such as TNF-α or IFN-γ, neither the overall expression of cytotoxic molecules in NK cells contacting MM target cells (Fig. 5); moreover, only slight differences were detected in the expression of activating and inhibitory receptors mostly involved in NK cell-mediated immunosurveillance (Supplementary Figs. 9 and 10).