Indeed, overactivation of CRLs has been characterized in tumor growth and progression and the enzymes implicated in the neddylation pathway (e.g., NAE1/UBA3, UBE2M/UBE2F, NEDD8 E3 ligases) are often overexpressed in different human cancers, including MM [59]. Here, NAE1 is linked to Miyoshi myopathy.