In this regard, our data seem to be consistent with a recent work from other laboratories exploring GTPases-associated pathways affected in Hemophagocytic Lymphohistiocytosis (HLH) with deficiency of RhoG, where lymphocyte exocytosis is abrogated without impairment of stable conjugates formation, activating receptors signaling and cytokine production. Here, RHOG is linked to hemophagocytic syndrome.