LAMP1 and Miyoshi myopathy: Using fresh isolated PBMCs from healthy donors, untreated or treated with the drug MLN4924 (150 nM) for 72 h, we analyzed by flow cytometry the cell surface expression of the lysosomal marker CD107a (a surrogate marker for cytotoxic granule exocytosis) on gated NK cells (Supplementary Fig. 1) upon interaction with different human MM cell lines [SKO-007(J3), ARK, RPMI 8226].