AGO2 and Hyperglycemia: Notably, we observed inhibition of PITPNA in ND human islets incurred a reduction of AGO2 expression and this may indicate (1) the beta-cell neutralizes miRNA-mediated gene regulation to counter hyperglycemia during T2D and (2) loss of AGO2 expression in T2D islets may characterize a late phase of the disease where compensatory proliferation of the beta-cell has been compromised42.