PITPNA and type 2 diabetes mellitus: Indeed, lentiviral-mediated induction of PITPNA in isolated islets from T2D human donors significantly elevated PITPNA expression levels in islets of the T2D donor (T2D-PITPNA OE), and these levels were comparable to the endogenous expression levels recorded for islets of the ND human donor (ND) (Fig. 7a).