We investigated the TCGA ccRCC data and found that 7q gain tumors had a higher level of pS6K (P70S6KP T389, Wilcoxon rank-sum test, p = 0.03) and mTOR signaling scores than 7q WT tumors (Wilcoxon rank-sum test, p < 0.01) (Supplementary Fig. 6f). The gene discussed is MTOR; the disease is nonpapillary renal cell carcinoma.