Patients with MDD exhibited significantly higher ALT in state #6 (t-value = 2.66, effect-size = 0.21, p = 0.007) and significantly lower ALT in states #2 and #4 compared to healthy controls (state #2: t-value = 3.21, effect-size = 0.25, p = 0.001; #4: t-value = 3.32, effect-size = 0.27, p < 0.001); adjusted for age and gender, Bonferroni corrected (states #1, #4 and #6: Fig. 2; states #2, #3 and #5 Supplementary Fig. 4). This evidence concerns the gene GPT and major depressive disorder.