TYR and albinism: These can be caused by variants in genes encoding: melanogenic enzymes (TYR, TYRP1 and DCT); channels regulating melanosomal pH (OCA2 and SLC45A2) or calcium homeostasis within melanin-containing cells (SLC24A5); subunits of multiprotein complexes that are involved in melanosome maturation and/or trafficking of melanogenic enzymes (Hermansky-Pudlak syndrome [HPS] group of genes).2 Most forms of albinism are inherited as autosomal recessive traits apart from GPR143-related albinism, which is an X-linked recessive condition.