To investigate the pathophysiological role of β1AR and A1R in cardiac autonomic dysfunctions associated with PD, we studied the effects of βAR agonists (isoproterenol, ISO), and selective antagonists of β1AR-selective (atenolol, AT) or A1R (1,3-Dipropyl-8-Cyclopentyl Xanthine, DPCPX), on the incidence of Ventricular Arrhythmias (VA), Atrioventricular Block (AVB) and Lethality (LET) induced by Cardiac Ischemia/Reperfusion (CIR) in the 6-OHDA model of PD. The gene discussed is ADRB1; the disease is Parkinson disease.