Here, we found that the expression of Adgre1 in both bone marrow and spleen (nests of immature and mature myeloid-derived immune cells, respectively) is significantly induced by melanoma cell inoculation 3 days p.i. This suggests that one or several adhesion GPCRs may be involved in the early response to injected tumor cells in mice. The gene discussed is ADGRE1; the disease is neoplasm.