ADGRE1 and melanoma: Three days after inoculation, before the melanoma popped up at the inoculation site, the mice were killed, and various organs were collected for detection of the mRNA expression levels of the potential mammalian homologues of mthl1. As demonstrated in Fig. 6, Adgre1, which is the potential mammalian homologue of mthl1 with the highest sequence similarity, was significantly up-regulated upon melanoma cell injections (as compared to control), in samples from spleen and from white blood cells derived from bone marrow.