CD8A and neoplasm: Tumor-specific IL-7Rhi CD8+ T cells (cluster 4) expressed intrinsic cytotoxic mediators including natural killer cell granule protein 7 (Nkg7), killer cell lectin receptor D1 (Klrd1), cathepsin W (Ctsw), cystatin F (Cst7), and Ccl5 (Fig. 4B), suggesting a capacity for cytotoxicity.