These dominant antigen models uniformly form tumors in immune competent mice but are robustly immunogenic (SI Appendix, Fig. S1B) and recapitulate key properties of human melanoma in the context of immunotherapy, including response to PD-1 and CTLA-4 blockade (SI Appendix, Fig. S1C), presence of progenitor-exhausted and exhausted T cell populations (SI Appendix, Fig. S1D) and response to adoptive cell transfer (SI Appendix, Fig. S1E) while facilitating interrogation of antigen-specific T cells. The gene discussed is PDCD1; the disease is melanoma.