SLC4A10 and Alkalosis: Indeed, seizure susceptibility to pentylenetetrazole (PTZ) and hyperthermia-induced hyperventilation with respiratory alkalosis were diminished in Slc4a10 knockout mice.22 Whether patients with SLC4A10-related disease are at increased risk of developing seizures is as of yet unclear, and in our study only 2 out of 10 patients had a clear history of epilepsy.