IFNA1 and dengue disease: In the case of sulforaphane (SFN), amplification of antiviral interferon (IFN) responses via NRF2 in infected nasal epithelial cells was suggested as an antiviral mechanism against influenza A virus (IAV) [12] and increased IFN responses due to activation of HMOX1 by NRF2 were part of the mechanisms restricting Dengue virus infection in cell-based models and suckling mice [4].