PIK3C2A and thrombocytosis disease: Moreover, important laboratory parameters predicting a worse prognosis included: increased concentrations of BUN [42], creatinine [43], serum glucose [44], AST [45], increased AST–ALT ratio [46], LDH [47], creatinine phosphokinase (CPK) [48], CRP [49], procalcitonin [50], ferritin [51, 52], altered blood count parameters, such as leucocytosis, leukopenia [53], lymphocytosis [54], lymphopenia [53], altered neutrophil and lymphocyte index [55], thrombocytopenia [56], and thrombocytosis [55], as well as, alteration of the prothrombin time [57], and increase in the concentration of D-dimer [52].