Results from dominant and additive APOE ε2 models were, in general, similar (eTables 2 and 3 in Supplement 2); however, prior literature indicates White individuals with an APOE ε2/ε3 genotype have a significantly lower risk of AD compared with individuals with the APOE ε2/ε2 genotype.6 Whether this holds true among Black individuals is unclear, again highlighting the need for even larger sample sizes of racially diverse individuals. The gene discussed is APOE; the disease is Alzheimer disease.