These results are in line with previous studies, which have reported as much as a 3-fold increase in the odds of developing AD for those with the ε2/ε4 genotype.57,58,59,60 We also conducted age-stratified sensitivity analyses to determine if significant sex × APOE interactions on cognition differed between participants younger than 75 years and participants 75 years or older at baseline. This evidence concerns the gene APOE and Alzheimer disease.