A direct statistical association between AH TGF-β2 and IOP has not been definitively established previously in either human patients with glaucoma or animal models, whereas weak to moderate associations between the other TGF-β isoforms (TGF-β1 and -β3) in AH and IOP have been reported in human patients with POAG.36 Here, TGFB1 is linked to open-angle glaucoma.