,74 Although increased AH concentrations of secreted proteins in glaucoma could conceivably reflect reduced egress from the eye via the compromised aqueous outflow pathways, we observed increased intensity of mRNA expression and TGF-β2 immunolabeling of non-pigmented ciliary and lens epithelia consistent with enhanced local production of the cytokine, rather than simply reduced outflow. This evidence concerns the gene TGFB2 and glaucoma.