After excluding outlier genetic variants (i.e., SNVs rs6475604 at CDKN2B-AS1 and rs33912345 at SIX6 for POAG, and SNV rs429358 at APOE for myopic RE) as the source of most of the observed heterogeneity, genetically determined POAG and RE were confirmed to be associated with cataract risk (Table). The gene discussed is CDKN2B; the disease is open-angle glaucoma.