The five top canonical pathways associated with our global data set included the synaptogenesis signaling pathway, spliceosomal cycle, androgen signaling, Huntington’s disease signaling, and 14–3-3-mediated signaling (Table 1), while our mitochondrial only data set was linked to mitochondrial dysfunction, sirtuin signaling pathway, oxidative phosphorylation, xenobiotic metabolism AhR signaling pathway, and geranylgeranyl diphosphate biosynthesis I (via mevalonate) (Table 1). The gene discussed is AHR; the disease is Huntington disease.