CBSmRNA -destabilizing lncRNA (lncRNA-CBSLR) induced by hypoxia integrated with YTH domain family protein 2 (YTHDF2) to decrease CBSmRNA stability, reducing the methylation of the Acyl-CoA synthetase long-chain family member 4 (ACSL4) and leading to degradation of ASCL4, which is conducive to protect gastric cancer (GC) cells from ferroptosis (Yang et al. 2022a). The gene discussed is ACSL4; the disease is gastric cancer.