Activating Nrf2/HO-1 signaling pathway reduces hypoxia/reoxygenation (H/R)-reduced ferroptosis of cardiomyocytes by icariin (ICA), while levistilide A (LA) activities Nrf2/HO-1 signaling pathway to promote ferroptosis in breast cancer (BC) (Liu et al. 2021b; Jing et al. 2022). The gene discussed is NFE2L2; the disease is breast cancer.