In addition, RAS-selective lethal 3 (RSL3), an inhibitor of GPX4, bonds with GPX4, which effectively leads to lipid peroxides and downregulates ion GPX4 in glioblastoma, resulting in ferroptosis of glioblastoma (Li et al. 2021c; Hu et al. 2022). This evidence concerns the gene GPX4 and glioblastoma.