The clinical, biochemical, and histopathological characteristics of these two cats with NP were similar to those of NPC rather than those of NP type A. Consequently, we analyzed the feline NPC1 and NPC2 genes after confirming the absence of the SMPD1:c.1017G>A (p.W339*) mutation that was recently reported in a Siamese cat with NP type A [20]. This evidence concerns the gene NPC2 and nasopharyngeal carcinoma.