Using WGCNA, we confirmed AURKA, ITGB2, CTSS, and TYROBP as hub genes, which were identified in the coexpressed modules in PER♂, whereas AURKA was identified as a hub gene in PER♀, and these hub genes have been associated with obesity comorbidities (86–88). The gene discussed is CTSS; the disease is obesity due to melanocortin 4 receptor deficiency.