They hypothesized that there may be a subset of CRC that may be arising due to an accumulation of certain bile acids, in line with previous report by Payne et al. It is intriguing that the GM:F344 group had a high prevalence of tumors that exhibit monoallelic silencing of Apc; however, methylation analysis of Apc and the genome of tumors will need to be addressed in future studies. This evidence concerns the gene APC and colorectal carcinoma.