Collectively, the results of our study suggested that CERS6-derived CER (d18:1/14:0) and CER (d18:1/16:0) may inhibit PINK1/Parkin-regulated mitophagy, impeding the clearance of damaged mitochondria in RTECs, aggravating renal interstitial fibrosis and DKD. This evidence concerns the gene CBLN1 and diabetic kidney disease.