CERS6 and obesity due to melanocortin 4 receptor deficiency: Raichur et al. (25) screened antisense oligonucleotides that could effectively knockdown the expression of Cers6 in vivo, and successfully knockdown the expression of Cers6 and CER (d18:1/16:0) in obese and diabetic mice, importantly, ameliorated their insulin resistance, hyperglycemia, and obesity phenotypes.