PTGS2 and multiple sclerosis: COX2 deletion orCOX2 inhibition by celecoxib or EP2 inhibition by a dual EP2/EP1 antagonistAH6809 (Figure 2) reducedoligodendrocyte apoptosis, degree of demyelination and motor dysfunctionin a cuprizone-induced model of multiple sclerosis.31 It is very important to note that several of these centralnervous system disorders are associated with cognitive impairmentand motor disabilities.