PTGS2 and central nervous system cancer: Additional experiments inthis study indicate that glioblastomas typically display angiogenesishallmarks (determined by platelet endothelial cell adhesion molecule1 or CD31), which were increased by COX2 overexpression and then decreasedby EP2 antagonist TG6-10-1 treatment indicating the role of EP2 inCOX2 driven angiogenesis of gliomas.