PTGS2 and endometriosis: COX2 is up-regulated in endometriotic tissue and eutopic endometrialtissue, which synthesize a high level of PGE2 contributingto pathogenesis and exacerbation of endometriosis disease.40,41 Inhibition of COX2 decreases survival, migration, and invasion ofendometriotic cells that are associated with decreased PGE2.