In addition, BECs secrete neurotrophins, such as brain-derived neurotrophic factor (BDNF), insulin-like growth factor 1 (IGF1), and vascular endothelial growth factor (VEGF), to maintain normal brain homeostasis, suggesting that neurotrophic factors are a potent drug candidate for stroke therapy [238, 241]. The gene discussed is IGF1; the disease is stroke disorder.