Risk-reducing oophorectomy, if undertaken in a premenopausal woman, may also result in a reduction in breast cancer risk for women who have completed their families if BRCA2 gene carriers.20 Use of tamoxifen and aromatase inhibitors may also be added to the risk-management strategy, although once again is more likely to be effective in BRCA2 gene carriers due to the biological subtypes of cancer predisposed to. This evidence concerns the gene BRCA2 and breast carcinoma.