BRCA2 and breast cancer: Risk-reducing oophorectomy, if undertaken in a premenopausal woman, may also result in a reduction in breast cancer risk for women who have completed their families if BRCA2 gene carriers.20 Use of tamoxifen and aromatase inhibitors may also be added to the risk-management strategy, although once again is more likely to be effective in BRCA2 gene carriers due to the biological subtypes of cancer predisposed to.