PTEN and Alzheimer disease: However, unlike the induction of pS2152FLNA by exogenous Aβ42, incubation of control lymphocytes with Aβ42 did not reduce the FLNA—PTEN interaction to levels comparable to AD lymphocytes, suggesting that the time needed to dissociate PTEN tethering to FLNA may be longer than the time needed to hyperphosphorylate FLNA in response to Aβ42.