MTOR and Alzheimer disease: Overactive mTORC1 signaling has been demonstrated in AD postmortem hippocampus by elevated phosphorylated serine2448 (pS2448) mTOR, indicating mTORC1 activation (Talbot et al., 2012; Tang et al., 2015; Majd and Power, 2018), in mouse models of AD (Caccamo et al., 2010) and in AD patient lymphocytes (Paccalin et al., 2006).