We previously demonstrated that FLNA in AD brain and lymphocytes aberrantly links to α7AChR and to TLR4, and these aberrant protein interactions (and resulting pathologies) are disrupted by simufilam and induced by Aβ42 (Wang et al., 2012; Wang et al., 2017; Wang et al., 2020). This evidence concerns the gene TLR4 and Alzheimer disease.