Additionally, overactive mTOR and activated p70S6K (a downstream kinase used to confirm mTORC1 activation) are found in brains of AD transgenic mice (Caccamo et al., 2010) and can be induced by injection of Aβ42 into hippocampi of wildtype mice (Caccamo et al., 2011). Here, MTOR is linked to Alzheimer disease.