The fact that pS2152FLNA levels are elevated by incubation with exogenous Aβ42 indicates that soluble Aβ42 in AD brain or lymphocytes (Meng et al., 2019) can activate kinase(s) such as mTOR (Shaw, 2011) to phosphorylate FLNA. The gene discussed is MTOR; the disease is Alzheimer disease.