Klotho levels are strongly correlated with chronic kidney disease and renal failure, and individuals with obesity are at a greater risk for developing these conditions (Kim et al., 2018; Lakkis and Weir, 2018; Nehus, 2018; Cheikhi et al., 2019; Chen et al., 2021). Here, KL is linked to obesity due to melanocortin 4 receptor deficiency.