We observed the dysregulation of several transcripts related to the ubiquitin-proteasomal system in AD and autophagy in aged platelets, two proteolytic pathways involved in the regulation of platelet function (Feng et al., 2014; Gupta et al., 2014; Ouseph et al., 2015; Colberg et al., 2021). The gene discussed is UBB; the disease is Alzheimer disease.