While in aging, chronic systemic inflammation, particularly to elevated plasma levels of TNF-alpha, was recently linked to platelet hyperactivity (Davizon-Castillo et al., 2019), in AD, amyloid beta peptides (Abeta) might drive enhanced platelet activation (Shen et al., 2008; Canobbio et al., 2014; Sonkar et al., 2014; Donner et al., 2016). The gene discussed is APP; the disease is Alzheimer disease.