Interestingly, we also observed the upregulation of hypoxanthine phosphoribosyltransferase 1 (HPTR1), a positive regulator of GDP and GTP synthesis (Wolff et al., 2022) among elderly (AD versus Young and Old versus Young); and GNB1, the beta subunit of G proteins, and of several GTPases (RAC1, RAC2, SAR1A, RAB14 and Rab11B) and GTPases associated proteins (ARHGDIA and ROCK2) in AD (AD versus Old). The gene discussed is RAC1; the disease is Alzheimer disease.