COTL1 and Alzheimer disease: In AD versus Young samples, significantly enriched gene ontology (GO) terms included platelet alpha granule lumen (e.g., TMSB4X, PPBP, PF4, MMRN1), platelet activation (GP1BB, VCL, CD9, GP9, PF4, PLEK, GP5, MMRN1, MYL9, TREML1, UBASH3B), regulation of platelet activation (GP1BB, CD9, GP9, PLEK, GP5, MMRN1, UBASH3B) and actin cytoskeleton organization (COTL1, TMSB4X, SLC9A3R1, ARPC5, PLEK, INF2, MYL9, PARVB) (Supplementary Data S1).