VCL and Alzheimer disease: In AD, previous platelet proteomic studies showed dysregulation of several actin cytoskeleton binding proteins, including increased levels of tropomyosin (Veitinger et al., 2014; Reumiller et al., 2018) and talin (González-Sánchez et al., 2018) and decreased levels of vinculin and moesin (González-Sánchez et al., 2018).