DEF6 and Alzheimer disease: In AD versus Old and AD versus Young, we identified 15 platelet DETs similarly regulated (Figures 6A, C), including transcripts related to the proteasome (PSMB8, PSMD12, NUB1), autophagy and vesicular trafficking (LYST (Holland et al., 2014), SETX (Richard et al., 2021; Richard and Rosonina, 2021)), cytoskeleton (TPM2, PAFAH1B1 (Markus et al., 2020) and GTPase regulation (DEF6 (Oka et al., 2007)).