COTL1 and Alzheimer disease: In our study cohort, AD and non-demented aged individuals showed a tendency towards higher levels of CD62P+ activated platelets (p-value > 0.05) and upregulation of several proteins linked to platelet activation and hemostasis in comparison with young subjects, including structural subunits of adhesive receptors (GP1BB, GP5, GP9, ITGA6); actin binding proteins involved in cytoskeletal remodeling (TMSB4X, VCL, PARVB, MYL9, COTL1, INF2); and granule proteins involved in coagulation (F13A1, PF4), platelet adhesion and aggregation (MMRN1, PDIA6, COTL1).