In this study, AD individuals showed upregulation of proteins linked to cytoskeleton reorganization (ARPC1B, ARPC3, ARPC5, MYLK, PAFAH1B1, RAC1, RAC2, ROCK2, TUBA8, TMBS4X), platelet adhesion (MMRN1), and cell signaling (GNB1, RAC1, RAC2, SAR1A, RAB14, Rab11B, ARHGDIA, ROCK2), changes that may contribute to platelet dysfunction in AD. This evidence concerns the gene MMRN1 and Alzheimer disease.