In this study, AD individuals showed upregulation of proteins linked to cytoskeleton reorganization (ARPC1B, ARPC3, ARPC5, MYLK, PAFAH1B1, RAC1, RAC2, ROCK2, TUBA8, TMBS4X), platelet adhesion (MMRN1), and cell signaling (GNB1, RAC1, RAC2, SAR1A, RAB14, Rab11B, ARHGDIA, ROCK2), changes that may contribute to platelet dysfunction in AD. The gene discussed is ARPC3; the disease is Alzheimer disease.