APP-PS1 mice are genetically engineered to overproduce amyloid beta and replicate several features of AD, including amyloid plaque pathology, gliosis and cognitive deficits (Jankowsky et al., 2004; Lalonde et al., 2005; Janota et al., 2015; Unger et al., 2016; Unger et al. 2018a; Unger et al. 2018b; Unger et al. 2020). This evidence concerns the gene APP and Alzheimer disease.