In line with this, Ldlr-/-.Leiden mice fed a HFD have been shown to develop hepatic dysfunction (van den Hoek et al., 2020; Gart et al., 2023) and the findings presented herein indicate that obese Ldlr-/-.Leiden mice also resemble human obesity-related brain pathology. This evidence concerns the gene LDLR and obesity due to melanocortin 4 receptor deficiency.