LDLR and atherosclerosis: The fact that Ldlr-/-.Leiden mice but not C57BL/6J mice develop mitochondrial dysfunction during aging on a chow diet advocates additional examination of the Ldlr-/-.Leiden mice as an aging model, the more so because these animals develop moderate visceral obesity and atherosclerosis on the long run, even on a normal chow diet (Verschuren et al., 2009; Gart et al., 2023).