Meanwhile, the blockade of hypocretin signaling in the BLA relieved the MPS-induced fear response, and partially reduced PTSD-like anxiety behaviors performed by the open field test (OFT) and elevated plus maze (EPM) task.<h4>Discussion</h4>Our findings suggest that the hypocretinergic system is a potential therapeutic approach for PTSD treatment. This evidence concerns the gene HCRT and post-traumatic stress disorder.