We hypothesized that dysregulated NAD metabolism contributes to these abnormalities.<h4>Methods</h4>RNAsequencing of lungs from transgenic mice expressing human ACE2 (K18-hACE2) challenged with SARS-CoV-2 revealed upregulation of NAD biosynthetic enzymes, including NAPRT1, NMNAT1, NAMPT, and IDO1 6 days post-infection.<h4>Results</h4>Our data also demonstrate increased gene expression of NAD consuming enzymes: PARP 9,10,14 and CD38. Here, NAMPT is linked to infection.