RAMP1 and pulmonary fibrosis: Although lung fibrosis in Ramp1-/- mice was slightly increased under control diet-fed conditions, fibrosis significantly increased in Ramp1-/- mice under alcohol diet-fed conditions compared with control mice, as evidenced by the staining of H&E and Masson’s trichrome, the pathology score and collagen deposition (Figures 7A–D).