Due to this protective role of Nrf2, studies are focusing on synthetic drugs, including, dihydroartemisinin, and dimethyl fumarate, as well as natural compounds, including sinomenine, licochalcone, 7-deacetyl-gedunin, calycosin and resveratrol, that increase the expression of Nrf2 to treat RA (170–174; 90). The gene discussed is NFE2L2; the disease is rheumatoid arthritis.