NFKB1 and rheumatoid arthritis: Numerous studies have shown the effect of celastrol on actively improving RA severity through suppression of the following: ROS-NF-κB-NLRP3 signaling (37), HIF expression and ROS release (36), the PI3-K/AKT/mTOR axis (45, 46) and NF-κB by degrading IκB (44, 47).