Collectively, our data show that these downregulated miRNAs of active TB were found to mediate mTOR signaling, TGF-β signaling, Wnt signaling, Hedgehog signaling, chemokine signaling, apoptosis, Fc gamma receptor-mediated phagocytosis, and oxidative phosphorylation with relevance to monocytic functions during TB disease. The gene discussed is TGFB1; the disease is tuberculosis.