Some of the TB-associated functions mediated by the downregulated miRNAs of active disease versus latent infection are as follows: i) DS-TB vs LTB: TGF-beta signaling pathway and mTOR signaling pathway; and ii) DR-TB vs LTB: Wnt signaling pathway, calcium signaling pathway, and hedgehog signaling pathway. Here, MTOR is linked to disease arising from reactivation of latent virus.