The enriched functions for the active disease versus the healthy controls are i) DS-TB vs HC: VEGF signaling pathway, oxidative phosphorylation, and Fc gamma R-mediated phagocytosis and ii) DR-TB vs HC: inflammatory mediator regulation of TRP channels, chemokine signaling pathway, apoptosis-multiple species, C-type lectin receptor pathway, cytosolic-DNA sensing pathway, and phospholipase D signaling pathway. This evidence concerns the gene CLEC4D and tuberculosis.