On recognition of tumor cells, NK cells secrete cytokines such as IFN-γ, GM-CSF, G-CSF, M-CSF, TNF, IL-5, IL-10, and IL-13 to exerts immunoregulatory functions, including inhibition of tumor development, promoting DC recruitment and maturation, improving presentation of tumor antigens, as well as directly regulating activation, proliferation, and effects of T cells (7). This evidence concerns the gene IL10 and neoplasm.