CCL2 and neoplasm: In the mouse breast tumor model, 2.5×10 (6) MDA-MB-231 or 10 (6) LM2 tumor cells were orthotopically injected into the inguinal mammary gland of severe combined immunodeficiency (SCID) beige or nude mice respectively, blocking the CCL2-CCR2 axis with anti-CCL2 antibody can effectively inhibit macrophage recruitment and thus inhibit breast tumor metastasis (107).