designed CAR with a glucocorticoid-induced TNFR-related protein (GITR) co-stimulatory domain and recorded that EGFR-GITR-CD3 CAR-T cells were cytotoxic against EGFR+ pancreatic and ovarian cancer cells with higher levels of IFN-γ (98). This evidence concerns the gene TNFRSF18 and ovarian carcinoma.