Before that, rs11571319 has not been reported previously related to RA risk, and it had just been reported to be susceptible to primary biliary cirrhosis (46), asthma (47), and so on.Regarding the PDCD1 gene, there is currently no literature on the association between rs5839828 and diseases, but another significant SNP of this gene, rs36084323, was associated with the risk of RA (48) and cancers (49). This evidence concerns the gene PDCD1 and asthma.