Further, some gene targets already investigated in the ACT of osteosarcoma, including B4GALNT1 (encoding beta‐1,4‐N‐acetyl‐galactosaminyltransferase 1 involved in the biosynthesis of GD2), ERBB2, and EGFR, also showed low expression in osteosarcoma compared with adjacent normal tissues (Figure 1F). This evidence concerns the gene ERBB2 and osteosarcoma.