A series of studies demonstrated that NEP inhibition enhanced the activity of natriuretic peptide systems causing natriuresis, diuresis, vasodilatation, and inhibition of renin‐angiotensin system (RAS), which could act as a potentially beneficial counter‐regulatory system in RAS activation states such as chronic heart failure and CKD.10, 11, 12. The gene discussed is MME; the disease is chronic kidney disease.