We read with interest the article by Sreedevi et al who reported the case of a 12-year-old girl with a congenital disorder of glycosylation (CDG) due to the variant c.710C > T in the phosphomannomutase-2 (PMM2) gene.1The patient manifested phenotypically with developmental delay, cognitive impairment, generalized hypotonia, and paraplegia.1It was concluded that couples with infertility or miscarriage and a child with CDG should undergo molecular genetic testing.1The study is excellent but has limitations that should be discussed. This evidence concerns the gene PMM2 and congenital disorder of glycosylation.