Higher levels of SAT and VAT were associated with worsening cognitive function in men even after controlling for metabolic disorders, adipocytokines (adiponectin, IL-6, tumor necrosis factor α [TNF-α], and plasminogen activator inhibitor-1[PAI-1]), and sex hormone levels (estradiol and testosterone) (56). This evidence concerns the gene PLXNA3 and Other metabolic disease.