And CENPA can recruit histone acetyltransferase (HAT) general control of amino acid synthesis (GCN)-5 to the karyopherin α2 subunit gene (KPNA2) promoter region to epigenetically activate its transcriptional activity, resulting in glycolysis and malignant growth in colon cancer (CC) cells (77). This evidence concerns the gene KPNA2 and colonic neoplasm.