KPNA2 and malignant colon neoplasm: And CENPA can recruit histone acetyltransferase (HAT) general control of amino acid synthesis (GCN)-5 to the karyopherin α2 subunit gene (KPNA2) promoter region to epigenetically activate its transcriptional activity, resulting in glycolysis and malignant growth in colon cancer (CC) cells (77).