ESR2 and cyclic hematopoiesis: As shown in Figure 5C, 8-OHdG positive cells (green arrow) were observed in atrophied lacrimal glands in LGBLEL, and only a few positive cells were found in lymphocyte infiltration areas; in the controls, 8-OHdG was also detected in some lacrimal cells in ERβ-negative LGB and in some fibrocytes in the intervascular fibrous connective tissues of CH (Figure 5C and Supplementary Figure 2).