Because we observed that, in LGBLEL, increased expression of ERβ and estrogen receptor cell proliferation inhibitor genes, such as RERG RNA reduced and RERG, can inhibit cell proliferation and tumor formation (37), we next evaluated the effect of RERG on the regulation of lymphocyte infiltration and lacrimal gland atrophy in LGBLEL. The gene discussed is ESR1; the disease is neoplasm.