ESR1 and cyclic hematopoiesis: The IHC results showed that ERβ [encoded by the estrogen receptor 2 (ESR2) gene] was observed in almost all lacrimal glands and some lymphatic cell-infiltrated areas, ERα [encoded by the estrogen receptor 1 (ESR1) gene] was rarely expressed in the lacrimal glands or lymphatic cell-infiltrated areas in LGBLEL, while ERα and ERβ were both expressed in the vessel wall and fibrotic areas in CH (Figure 1B).