MiR-129-5p in BMSC-Exos protected OGD-treated HL-1 cell by inhibiting TRAF3 expression. The study of Shuo Upregulating miR-129-5p in BMSCS-Exo could directly inhibit HMGB1 at the site of cardiac injury in mice, thereby protecting MI mouse cardiac function. Here, TRAF3 is linked to myocardial infarction.