IGF1 and Infertility: Studies on Igf1 null mice reveal the development of immature ovaries concomitant with infertility and non-responsiveness towards exogenous gonadotropins (Kadakia et al., 2001), while in vitro administration of IGF1 promotes oocyte maturation, fertilization, and embryo development in bovine, canine and mice oocytes (Lorenzo et al., 1994; Toori et al., 2014; Sato et al., 2018).