When CAR-T cells destroy tumor cells, the tumor components are released into the adjacent and surrounding tissues, immune cells are rapidly activated, systemic inflammatory cytokines such as IL-6, IFN-γ, and C-reactive protein (CRP) are secreted, and cytokine release syndrome (CRS), neurotoxicity and in severe cases, death may ensue (Chou and Turtle, 2020). This evidence concerns the gene IL6 and neoplasm.