Compared to ROR1-CARs cells without short “Hinge-only” extracellular spacer, those with the foregoing structure more effectively lysed ROR1 (+) tumor cells and potentiated T cell effector function against primary chronic lymphocytic leukemia (CLL) and ROR1 (+) epithelial cancer lines without triggering activation-induced T cell death (Hudecek et al., 2013). Here, ROR1 is linked to B-cell chronic lymphocytic leukemia.